Pharmacologic Substance
quetiapine fumarate
Effect:
Decreased Dopamine Activity; Decreased Histamine Activity; Decreased Norepinephrine Activity; Decreased Serotonin Activity
May Treat:
Autistic Disorder; Bipolar Disorder; Depressive Disorder, Major; Psychotic Disorders; Schizophrenia
More Information:
ChemID; DailyMed; DrugInfo; PDR
Definitions related to quetiapine fumarate:
  • A dibenzothiazepine and ANTIPSYCHOTIC AGENT that targets the SEROTONIN 5-HT2 RECEPTOR; HISTAMINE H1 RECEPTOR, adrenergic alpha1 and alpha2 receptors, as well as the DOPAMINE D1 RECEPTOR and DOPAMINE D2 RECEPTOR. It is used in the treatment of SCHIZOPHRENIA; BIPOLAR DISORDER and DEPRESSIVE DISORDER.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2021
  • The fumarate salt form of quetiapine, a dibenzothiazepine derivative with antipsychotic property. Quetiapine fumarate antagonizes serotonin activity mediated by 5-HT 1A and 5-HT2 receptors. With a lower affinity, this agent also reversibly binds to dopamine D1 and D2 receptors in the mesolimbic and mesocortical areas of the brain leading to decreased psychotic effects, such as hallucinations and delusions. In addition, quetiapine fumarate also binds to other alpha-1, alpha-2 adrenergic and histamine H1 receptors.
    NCI Thesaurus
    U.S. National Cancer Institute, 2021
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This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.