Pharmacologic Substance
zafirlukast Audio
[ zuh-fer-loo-kast ]
Brand Names:
Accolate
Effect:
Bronchodilation; Decreased Tracheo-Bronchial Mucosal Edema
May Prevent:
Asthma
May Treat:
Asthma
More Information:
ChemID; DrugBank; DailyMed; DrugInfo; PDR
Definitions related to zafirlukast:
  • A drug used to prevent and treat symptoms of asthma. It blocks substances that cause inflammation in the lungs. It is a type of antiasthmatic agent and a leukotriene receptor antagonist.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
  • A tolyl compound and leukotriene receptor antagonist (LTRA), with anti-asthmatic and potential capsular contracture-preventing activities. Upon administration, zafirlukast selectively and competitively binds to and blocks the cysteinyl leukotriene 1 receptor (CYSLTR1), thereby preventing the potent pro-inflammatory mediators leukotriene C4, D4 and E4 from binding. This prevents leukotriene-mediated actions, including enhanced migration of eosinophils and neutrophils, increased adhesion of leukocytes, increased monocyte and neutrophil aggregation, increased airway edema, inflammation, capillary permeability and bronchoconstriction. In addition, zafirlukast may decrease collagen deposition, fibrosis, and capsular thickness after implantation, thereby preventing scar tissue.
    NCI Thesaurus
    U.S. National Cancer Institute, 2021
  • Accolate (zafirlukast) dosing, indications, interations, adverse effects, and more.
    Medscape
    WebMD, 2019
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This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.