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Pharmacologic Substance
Zafirlukast
A tolyl compound and leukotriene receptor antagonist (LTRA), with anti-asthmatic and potential capsular contracture-preventing activities. Upon administration, zafirlukast selectively and competitively binds to and blocks the cysteinyl leukotriene 1 receptor (CYSLTR1), thereby preventing the potent... NCI Thesaurus more
A tolyl compound and leukotriene receptor antagonist (LTRA), with anti-asthmatic and potential capsular contracture-preventing activities. Upon administration, zafirlukast selectively and competitively binds to and blocks the cysteinyl leukotriene 1 receptor (CYSLTR1), thereby preventing the potent pro-inflammatory mediators leukotriene C4, D4 and E4 from binding. This prevents leukotriene-mediated actions, including enhanced migration of eosinophils and neutrophils, increased adhesion of leukocytes, increased monocyte and neutrophil aggregation, increased airway edema, inflammation, capillary permeability and bronchoconstriction. In addition, zafirlukast may decrease collagen deposition, fibrosis, and capsular thickness after implantation, thereby preventing scar tissue. NCI Thesaurus
Brand Names:
Accolate
Effect:
Bronchodilation; Decreased Tracheo-Bronchial Mucosal Edema
May Prevent:
Asthma
May Treat:
Asthma
Mechanism:
Leukotriene Receptor Antagonists
More Information:
ChemID; DrugBank; DailyMed; DrugInfo; PDR
Always consult a medical professional for advice (Terms) Use Notice Feedback Sources
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zafirlukast
Medscape
Accolate (zafirlukast) dosing, indications, interations, adverse effects, and more.
Images:
  • Zafirlukast image from Wikimedia
  • Zafirlukast image from Wikimedia
  • Wikimedia
Definitions:
zafirlukast
NCI Dictionary of Cancer Terms
A drug used to prevent and treat symptoms of asthma. It blocks substances that cause inflammation in the lungs. It is a type of antiasthmatic agent and a leukotriene receptor antagonist.
zafirlukast
NCI Dictionary of Cancer Terms
A drug used to prevent and treat symptoms of asthma. It blocks substances that cause inflammation in the lungs. It is a type of antiasthmatic agent and a leukotriene receptor antagonist.
Viewing results 1 - 10 of 280,000 (0.25 seconds)
  • Zafirlukast: MedlinePlus Drug Information
    Dec 15, 2017 ... Zafirlukast is used to prevent asthma symptoms. Zafirlukast is in a class of medications called leukotriene receptor antagonists (LTRAs).
    medlineplus.gov/druginfo/meds/a697007.html
  • Zafirlukast (Oral Route) Proper Use - Mayo Clinic
    Feb 1, 2022 ... Zafirlukast is used to prevent asthma attacks. It is not used to relieve an attack that has already started. For relief of an asthma attack ...
    mayoclinic.org/drugs.../zafirlukast-oral-route/.../drg-20066745
  • Zafirlukast: Uses, Interactions, Mechanism of Action | DrugBank Online
    Zafirlukast is an oral leukotriene receptor antagonist (LTRA) for the maintenance treatment of asthma, often used in conjunction with an inhaled steroid ...
    go.drugbank.com/drugs/DB00549
  • Zafirlukast (Oral Route) Side Effects - Mayo Clinic
    Feb 1, 2022 ... Zafirlukast is used to prevent asthma attacks. It is not used to relieve an attack that has already started. For relief of an asthma attack that ...
    mayoclinic.org/drugs.../zafirlukast-oral.../drg-20066745?p=1
  • Zafirlukast in Treatment of Marker Relapsed Ovarian Cancer - Full ...
    Apr 9, 2020 ... This is a single-arm Simon two-stage phase 2 clinical trial to determine whether zafirlukast reduces the tumor marker CA-125 as well the ...
    clinicaltrials.gov/ct2/show/NCT04339140
  • Zafirlukast | C31H33N3O6S - PubChem
    Zafirlukast is an orally available leukotriene receptor antagonist which is widely used for the prophylaxis and chronic treatment of asthma. Zafirlukast has ...
    pubchem.ncbi.nlm.nih.gov/compound/Zafirlukast
  • Accolate (zafirlukast) dosing, indications, interations, adverse effects ...
    USES: Zafirlukast is used to control and prevent symptoms (such as wheezing and shortness of breath) caused by asthma. Controlling symptoms of asthma helps you ...
    reference.medscape.com/drug/accolate-zafirlukast-343449
  • Zafirlukast Is a Dual Modulator of Human Soluble Epoxide ... - Frontiers
    Mar 20, 2019 ... The cysteinyl leukotriene receptor 1 antagonists (CysLT1RA) montelukast, zafirlukast and pranlukast (Figure 1) were initially developed for the ...
    frontiersin.org/articles/10.3389/fphar.2019.00263/full
  • Zafirlukast (Accolate): A New Treatment for Capsular Contracture ...
    Patients received a regimen of zafirlukast 20 mg by mouth 2 times daily for 3 months. Results. In many cases, dramatic softening of the breast capsule was ...
    academic.oup.com/asj/article/22/4/329/208528
  • Zafirlukast - Drugs and Lactation Database (LactMed) - NCBI ...
    May 1, 2019 ... No published information is available on the use of zafirlukast during breastfeeding; however, manufacturer's data indicate that the dose in ...
    ncbi.nlm.nih.gov/books/NBK501489/
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